There is insufficient evidence to recommend the exclusion or ingestion of coffee during treatment, so its consumption is optional. The current recommendation is that moderate coffee consumption can be part of a balanced diet. The EFSA (European Food Safety Agency) advises not to exceed an intake of 400 mg of caffeine per day (a dose which, spread over the day, has no harmful effects). It is important to keep in mind that caffeine content depends on the type of coffee or dilution (amongst other things) and that on average, a cup of espresso contains about 80 mg of caffeine. Therefore, it is best not to drink more than four cups of coffee a day. A high caffeine intake can interfere with sleep patterns, cause digestive problems, or lead to imbalances in blood pressure.